Protecting Americans from Dangerous Opioids Act

S 606, the "Protecting Americans from Dangerous Opioids Act," requires the Health Secretary to revoke approval of an existing opioid drug whenever a new opioid is approved. Specifically, the Secretary must prioritize revoking non-abuse deterrent opioid formulations and consider public health impact when choosing which drug to remove. This directly affects opioid manufacturers and prescribers by reducing the number of less-safe opioid options available on the market. The bill targets the opioid crisis by linking new drug approvals to the removal of existing high-risk medications, based on data showing overdose deaths have quadrupled since 1999.