To amend the Public Health Service Act to provide for the inclusion of a biological attribution strategy, and an early warning strategy and implementation plan, in the National Health Security Strategy, and for other purposes.

HR 4516 amends the Public Health Service Act to require federal agencies to develop two new strategies: a biological attribution strategy (to identify the source of biological threats like pathogens) and an early warning strategy (to detect threats earlier using new technologies). The bill mandates specific elements, including agency coordination, detailed processes for attribution, and plans for developing detection tools like sequencing and wastewater monitoring. It directly affects federal agencies such as the CDC, National Intelligence, and the Administration for Strategic Preparedness and Response. The law aims to improve coordination and early detection capabilities for biological, chemical, and radiological threats without specifying new funding or enforcement measures.