Holidays and Days of Special Observance - As enacted, designates October 1 of each year as "APDS Day" to promote awareness of activated PI3K delta syndrome. - Amends TCA Title 15, Chapter 2.

HB 1492 designates October 1 of each year as "APDS Day" in Tennessee to raise awareness about activated PI3K delta syndrome (APDS), a rare genetic immunodeficiency affecting approximately 1-2 people per million. The bill does not create new programs or alter existing laws but establishes an annual observance to highlight this condition, which causes frequent infections, developmental delays, and other health challenges. It specifically aims to support Tennesseans diagnosed with APDS and their families by promoting recognition of the disease. This is a commemorative resolution, not a substantive policy change.