Creates provisions relating to the 340B drug program

HB 781 requires covered entities (like safety-net hospitals and clinics participating in the federal 340B drug program) to use all 340B drug proceeds - defined as savings from discounted drug purchases - to either offset out-of-pocket costs for or provide direct patient care to **vulnerable patients** (uninsured individuals with income ≤400% of federal poverty level). Covered entities must annually certify compliance with this requirement by September 1, 2026, and report detailed usage of funds to the Department of Health and Senior Services. The bill mandates itemized reports on how proceeds were applied to vulnerable patients, including specific cost offsets and care services, while protecting patient privacy. It does not override federal law and authorizes the Department to investigate violations, including potential loss of state funding for noncompliance.